Pathogen Reduction technology
The Mirasol Pathogen Reduction Technology (PRT) System renders a broad range of disease-causing viruses, bacteria and parasites less pathogenic, and inactivates residual white blood cells found in blood components.
Built for efficiency and ease of use, the novel Mirasol PRT system helps improve the safety of the blood supply by reducing the infectious levels of disease-causing agents in platelets and plasma while still maintaining quality blood components
The Mirasol Pathogen Reduction Technology (PRT) System uses a combination of riboflavin (vitamin B2), a non-toxic, naturally occurring compound, and a specific spectrum of ultraviolet (UV) light to inactivate viruses, bacteria, parasites and white blood cells that may be present in collected blood products.
The Mirasol PRT system consists of three main components:
• A disposable kit — includes an illumination/storage bag and sterile riboflavin solution
• The Mirasol Illuminator — provides UV light and agitation for the Mirasol PRT process
• Mirasol® Managersoftware — integrates and manages data reporting and storage
During treatment, a blood product is mixed with the riboflavin solution and placed into the Illuminator where it is exposed to UV light for about five to ten minutes. There is no need to remove riboflavin or its photoproducts; after illumination, the treated products are ready for transfusion or placement into storage.
How the Mirasol PRT system inactivates pathogens and white blood cells:
UV light + riboflavin = irreversible inactivation
Riboflavin molecules associate with nucleic acids of pathogens. Exposure to UV light activates riboflavin and when it is associated with pathogen nucleic acid, riboflavin causes a chemical alteration to functional groups of the nucleic acids (primarily guanine bases), making pathogens unable to replicate.
Treating platelets and plasma in three simple steps:
1. The product is transferred to the Mirasol PRT illumination/storage bag
2. Riboflavin solution is added and mixed with the product
3. The mixture is then exposed to UV light for about five to ten minutes